Van de Ven Brace Halts The Toffees' Run at New Stadium
The Dutch defender emerged as the initial backline player to score twice in a Premier League game for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven heads home two times in opening period
The home side's Jake O'Brien has goal ruled after video check
Pape Matar Sarr scores final goal in dying moments
The defeat is the Merseyside club's first at their new ground
Micky van de Ven scored twice as Spurs prolonged their winning streak in away games in the top division and delivered Everton their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left Goodison Park behind after 133 years at the conclusion of last season.
But Tottenham's leader the Dutchman struck on two occasions from corners in the opening 45 minutes to place their strong form at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
The Everton defender thought he had equalized the scores a short while after the defender's opener, directing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of chances, while Vicario made a series of excellent stops to ensure Tottenham went five away games unbeaten in the English top flight.
But the video assistant referee intervened, instructing the match official to review the goal on the screen and the referee ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory moves the manager's side up to third in the Premier League, five points off north London rivals and leaders the Gunners.
The Merseyside club stay 14th and sit half a dozen points ahead of the drop zone.
Spurs breakdown: Van de Ven excels in duties at each end of pitch
Following a drab weekday display in the European competition against the French side, where they managed a mere two shots on target, the manager opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The summer signing was unable to influence the game before being substituted for Richarlison after an hour on the pitch, but it emerged he proved unnecessary in the end.
Defender Van de Ven converted into an offensive threat to be feared.
Spurs' first goal came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball back across the six-yard box for an free Van de Ven to score.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - added his next goal in first-half stoppage time as he outjumped Jordan Pickford to nod in.
Van de Ven was just as outstanding in defence, combining effectively with his defensive colleague as the pair dealt excellently with the 34 crosses sent their way by the opposition.
Toffees breakdown: Everton missing striker's instinct
Everton's new home had been a fortress, but it seems the novelty may have worn off somewhat and supporters headed to the gates after Sarr's third for Spurs.
The end in the team's winning streak at home won't be a major concern for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Toffees' pair of recognised strikers - had scored just a single goal between them before Sunday's outing.
And they were failed to contribute to that miserable tally on a damp and dreary night on Merseyside.
The striker's performance was epitomized when he chose to bicycle-kick a clear chance from close range, even with having space and opportunity to readjust for a more conventional shot that would have tested Vicario.
Barry, too, failed to influence the game after replacing the starter in the second half.
It was not for a shortage of chance. Most of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly whipped threatening crosses into the Tottenham penalty area.
Upcoming fixtures for both teams?
Everton: The team travel to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club travel to St James' Park on late October for their fourth-round League Cup match against Newcastle.